Efficient Synthesis of Submicrometer‐Sized Active Pharmaceuticals by Laser Fragmentation in a Liquid‐Jet Passage Reactor with Minimum Degradation

Abstract One challenge in the development of new drug formulations is overcoming their low solubility relevant aqueous media. Reducing particle size powders to a few hundred nanometers well‐known method that leads an increase due elevated total surface area. However, state‐of‐the‐art comminution techniques like cryo‐milling suffer from degradation and contamination drugs, particularly when sub‐micrometer diameters are aspired require long processing times. In this work, picosecond‐pulsed laser fragmentation liquids (LFL) dispersed particles liquid‐jet passage reactor used as wear‐free technique using hydrophobic oral model drugs naproxen, prednisolone, ketoconazole, megestrol acetate. Particle morphology characterized scanning electron microscopy (SEM) changes distributions upon irradiation quantified analytical centrifuge. The findings highlight superior efficiency setup, with 100 times higher fraction submicrometer (SMP) compared batch control, which enhances goes along minimal chemical (<1%), determined by attenuated reflection‐Fourier transform infrared spectroscopy (ATR‐FTIR), high‐performance liquid chromatography (HPLC), X‐ray diffraction (XRD). Moreover, underlying predominantly photo‐mechanically induced mechanisms organic microparticles (MP) discussed.